Design Rules for ‘Triple Helix’ Organizations
نویسندگان
چکیده
منابع مشابه
Rational design of a triple helix-specific intercalating ligand.
DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and thermal denaturation experiments suggest that benzo[f]pyrido[3, 4-b]quinoxaline derivatives inte...
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Cooperative research centers (CRCs) are a significant and growing “triple helix-based” vehicle for promoting cross sector collaboration, knowledge and technology transfer and ultimately innovation. Although there is a growing social science literature on these organizational structures, the management and “best practice” portion of this literature have tended to emphasize success stories and to...
متن کاملTriple Helix-Forming Oligonucleotide
Triple-helical DNA can be formed by oligonucleotides that bind as third strands of DNA in a sequencespecific manner in the major groove in homopurine/homopyrimidine stretches in duplex DNA. Such triple helix-forming oligonucleotides have been used to inhibit gene expression by blocking transcription factor access to promoter sites in transient expression assays. In an alternative approach to ge...
متن کاملMacrocyclic scaffold for the collagen triple helix.
[structure: see text] Three strands of natural collagen are linked by covalent bonds prior to their folding into a triple helix. We report on a synthetic collagen in which the strands are pendent on a rigid macrocyclic scaffold of C(3) symmetry. The scaffold confers substantial conformational stability upon the collagen triple helix and makes its folding independent of concentration, both desir...
متن کامل(antisense/antigene/hybrid duplex/triple helix)
Deoxyribonucleic guanidine is a potential antisense agent that is generated via the replacement ofthe negative phosphodiester linkages ofDNA [-O-(POj)-0-O with positively-charged guanidinium (g) linkages [-NH--C(=NH2) -NH-]. A pentameric thymidyl deoxyribonucleic guanidine molecule [d(Tg)4T-azido] has been shown to base pair specifically to poly(rA) with an unprecedented affinity. Both double a...
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ژورنال
عنوان ژورنال: Technology Innovation Management Review
سال: 2019
ISSN: 1927-0321
DOI: 10.22215/timreview/1283